* 일시 : 5/14(목) 16:00 –
* 연사 : 백민준 교수(카이트스 바이오및뇌공학과)
* 장소 : 벤처관 711호
* 제목 : Nanotheranostic Platforms for Image-Guided Surgery and Phototherapy of Solid Tumors
* 초록 : Achieving complete tumor resection with microscopic tumor-free margins is the most critical factor for ensuring long-term survival and minimizing recurrence in solid tumor surgery. Despite the advancement of fluorescence-guided surgery, a significant clinical challenge remains: macroscopically “complete” resections often leave behind microscopic residual disease at the margins, leading to a local recurrence rate of approximately 10%. To address this, there is an urgent need for innovative theranostic platforms capable of real-time detection and intraoperative elimination of these microscopic residuals.
In this study, we introduce a photobleaching-mediated charge–convertible nanoparticle (NP) system designed to enhance both diagnostic precision and therapeutic efficacy. The NPs utilize a heptamethine fluorophore that undergoes oxidative cleavage upon near-infrared (808 nm) laser irradiation, rapidly shifting the NP surface charge from zwitterionic to cationic. This spatiotemporally regulated charge switching significantly overcomes delivery barriers, enabling deep intratumoral penetration into dense tumor tissues and microscopic residues. When integrated with photodynamic and chemodynamic agents, this nanotheranostic platform not only provides high-contrast imaging for surgical guidance but also achieves robust antitumor efficacy in rectal cancer models. These findings highlight the potential of photo-triggered nanotheranostics to bridge the gap between macroscopic surgery and microscopic clearance, offering a transformative approach to preventing post-surgical recurrence in solid tumors.
- Keywords: Nanoparticles, Solid Tumor, Drug Delivery, Image-guided Phototherapy