* 일시 : 10/8(목) 16:30 –
* 연사 : 유경현 교수(숙명여자대학교)
* 장소 : 벤처관 711호
* 제목 : Spatial genome reorganization and oncogenic transcriptional control in hepatocellular carcinoma
* 초록 :
Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies globally, characterized by high recurrence rates and limited therapeutic efficacy due to intrinsic and acquired resistance. While epigenetic dysregulation is a recognized hallmark of tumor progression, the specific role of three-dimensional (3D) chromatin reorganization in driving oncogenic transcription remains to be fully elucidated. In this study, we investigated the impact of sustained phosphorylated STAT3 (p-STAT3) activation—a central oncogenic driver in HCC—on the spatial genome architecture. By integrating ChIP-seq, Hi-C, HiChIP, and transcriptomic profiling, we demonstrate that p-STAT3 actively reshapes the 3D chromatin landscape by promoting the formation of frequently interacting regions (FIREs) and reorganizing topologically associating domains (TADs). These structural alterations coordinate the robust expression of gene networks fundamentally linked to invasion, angiogenesis, and drug resistance. Notably, we found that these p-STAT3-driven chromatin conformations persist even following pharmacological inhibition of STAT3, suggesting that 3D genomic structural stability provides a physical basis for therapy resistance. Collectively, our findings underscore the functional significance of spatial genome reorganization in liver cancer progression and identify persistent chromatin dynamics as potential biomarkers and novel targets for therapeutic intervention.