* 일시 : 5/22(목) 16:30 –
* 연사 : 류지혜 연사(숭실대학교)
* 장소 : 벤처관 711호
* 제목 : Expression quantitative trait loci for ribosomal proteins and RNA polymerase subunits: From transcriptional control to phenotypic influence
*초록
Ribosomal proteins (RPs) and RNA polymerases (POLs) are crucial for precise gene expression and protein synthesis, serving pivotal roles in sustaining cellular function and adaptability. Genome-wide association analyses for expression level of 70 RPs have identified 18 expression regulatory quantitative trait loci (erQTLs) for 21 RPs at the protein level, but not at the mRNA or ribosome occupancy levels, indicating regulation at the translational stage. These protein QTLs (pQTLs) were all trans-acting and partially associated with long non-coding RNAs and microRNA-mediated control, suggesting intricate post-transcriptional regulatory mechanisms. A comprehensive analysis of GWAS–eQTL pairs revealed that genes encoding RPs, particularly RPS26, are significantly associated with a wide range of complex human traits across multiple tissues. Furthermore, brain-specific eQTLs for POLR3H, a component of POL III, were implicated in neurological disorders, underscoring its functional significance. This study highlights the genetic and regulatory diversity of RPs and POLs, highlighting their importance in gene expression control and their potential contributions to human complex traits.